Agenda
Thursday, November 11, 2010
4:30 Keynote Address:
Diverse Modes of Efficacy and Stimulus Bias of Allosteric Modulators of GPCRs
P. Jeffrey Conn, Ph.D.
Lee E. Limbird Professor of Pharmacology
Director, Vanderbilt Program in Drug Discovery, Department of Pharmacology
Vanderbilt University Medical Center
5:15 Cocktail Reception / Meet and Greet
Friday, November 12, 2010
7:45 - 8:15 Registration / Continental Breakfast
8:15 Chairperson's Opening Remarks
P. Jeffrey Conn, Ph.D.
Lee E. Limbird Professor of Pharmacology
Director, Vanderbilt Program in Drug Discovery, Department of Pharmacology
Vanderbilt University Medical Center
8:25 Quantitative Analysis Reveals Multiple Mechanisms of Allosteric Modulation of the mGlu5 Receptor in Rat Astroglia
Chris Langmead, Ph.D.
Head of Pharmacology
Heptares Therapeutics Limited
9:05 Group II Metabotropic Glutamate Receptors (mGluRs): Design, Synthesis and Evaluation of Small Molecule Modulators
Nicholas D. P. Cosford, Ph.D.
Associate Professor, Director, Medicinal Chemistry
Sanford|Burnham Medical Research Institute
9:45 Validating the Role of mGluR4 Receptors in the Physiopathology of Anxiety Using a Selective mGluR4 Positive Allosteric Modulator
Brice Campo, Ph.D.
Group Leader In-Vitro Pharmacology CNS
Addex Pharmaceuticals
10:25 Morning Refreshment Break
10:45 Lead Optimization in the Allosteric Realm: Identification of a Selective M1 Muscarinic Receptor Positive Allosteric Modulator
Scott Kuduk, Ph.D.
Senior Research Fellow
Merck & Co.
11:25 Hit Identification Strategies for Allosteric Modulators of G Protein-Coupled Receptors
Neil T. Burford, Ph.D.
Senior Research Investigator II
Applied Biotechnology
Bristol-Myers Squibb
12:05 Lunch
12:55 Allosteric and Biased GPCR Signaling in Drug Discovery
Professor Arthur Christopoulos, B.Pharm., Ph.D.
NHMRC Senior Research Fellow, Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences & Department of Pharmacology
Monash University
1:35 Allosteric Agonists of the Sphingosine 1-phosphate (S1P) Receptor S1P1 for Immune-mediated Diseases
Hugh Rosen, Ph.D.
Professor, Chemical Physiology
The Scripps Research Institute
2:15 Subunit-selective NMDA Receptor Potentiators
Stephen F. Traynelis, Ph.D.
Professor of Pharmacology
Emory University
2:55 Afternoon Refreshment Break
3:15 Quantifying Allosterism, Agonist Bias and Inverse Agonism
Frederick J. Ehlert, Ph.D.
Professor, Pharmacology, School of Medicine
University of California-Irvine
3:55 The Development of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
Colleen Niswender, Ph.D.
Associate Professor, Vanderbilt Program in Drug Discovery
Department of Pharmacology
Vanderbilt University Medical Center
4:35 The Development of mGlu2 PAMs: Identification of JNJ-40068782 as a Novel Tool Compound
Hilde Lavreysen, Ph.D.
Senior Scientist, Neurosciences
Johnson & Johnson Pharmaceutical R&D, a division of Janssen Pharmaceutica NV
5:15 End of Conference